Curcumin undergoes rapid biotransformation which may also account for its limited bioavailability. In addition, following oral administration, curcumin is poorly absorbed, resulting in lower blood concentration with most of it getting excreted in the faeces.
Use of curcuminoids in very high doses, however, is not desirable. It would be preferable to attempt to increase the bioavailability of the curcuminoids. Luckily, there are a number of highly bioavailable extracts available. This article discusses the indications of curcumin and reviews some of the enhanced extracts available.