Curcumin for depression
There evidence curcumin may have antidepresant and anxiolytic effects. The evidence from clinical trials is weak according to a meta-analysis. Disturbances in neurotransmitter activity involving serotonin, dopamine, noradrenaline and glutamate have been regularly observed in depression. Findings from animal trials have demonstrated curcumin can alter the concentrations and activity of many of these neurotransmitters. Clinical summary of clinical trials and reviews.
Curcumin Bioavailable Extracts
Curcumin undergoes rapid biotransformation which may also account for its limited bioavailability. In addition, following oral administration, curcumin is poorly absorbed, resulting in lower blood concentration with most of it getting excreted in the faeces. Use of curcuminoids in very high doses, however, is not desirable. It would be preferable to attempt to increase the bioavailability of the curcuminoids. Luckily, there are a number of highly bioavailable extracts available. This article discusses the indications of curcumin and reviews some of the enhanced extracts available.
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